Gq assembly's
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Gq assembly's
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WebAug 13, 2024 · The role of loop nucleotides in multimeric GQ assembly has received relatively little attention from researchers, and most studies investigating multimeric GQs have not analyzed the effects of loop length and sequence composition. Despite this, examples in which loop nucleotides affect GQ multimerization have been described. ... WebThe four-stranded GQ assembly is composed of stacks of two or more G-tetrads formed by multiple H-bonds and stabilized by metal ions (e.g.,K+,Na, etc.).14,21In general, intramolecular GQ is formed by sequences having four or more G-tracts, which involve in tetrad formation. The intervening nucleotides, which form the loops, connect the tetrads.
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WebFeb 2, 2024 · Vast G-quadruplexes (GQs) are primarily folded by one, two, or four G-rich oligomers, rarely with an exception. Here, we present the first NMR solution structure of a trimolecular GQ (tri-GQ) that is solely assembled by the self-trimerization of d (GTTAGG), preferentially in Na + solution tolerant to an equal amount of K + cation.
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